In response to the global COVID-19 pandemic, The Rockefeller University has launched numerous studies aimed at better understanding the biology of the SARS-CoV-2 virus and developing interventions to prevent and treat infections. Coronavirus-related projects have been launched in approximately one-fourth of the university’s labs, including those run by leaders in fields such as virology, immunology, genomics, structural biology, and many other fields.
Rockefeller scientists have been working to develop novel treatments and improved testing protocols, and are focused both on SARS-CoV-2 and other coronaviruses that may emerge in the future. Projects include the development of antibodies and other therapeutics capable of preventing or treating the infection; the search for small molecules that inhibit the activity of viral or human proteins required for viral replication; and the creation of new in vitro systems for testing potential treatments. Scientists are also taking several approaches to identify new vulnerabilities of the virus, including genomic studies of humans with unusual responses to infection and cell-based screens using CRISPR gene-editing technology.